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TEL: +886-2-28757391 E-mail: kslee@vghtpe.gov.tw |
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| Principal Investigator: Oscar Kuang-Sheng Lee | ||
| Education |
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| MD, School of Medicine, National Yang-Ming University (1993) | ||
| MSc, Institute of Orthopaedics, University College London (1999) | ||
| PhD, Centre for Biomedical Engineering, University College London (2002) | ||
| EMBA, National Chengchi University, Taiwan (2008) | ||
| Current Positions | ||
| Associate Professor, Institute of Clinical Medicine, National Yang-Ming University | ||
| Director, Stem Cell Research Centre, National Yang-Ming University | ||
| Attending Physician, Department of Medical Research and Education, and Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital | ||
| Jointly-appointed Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Taiwan | ||
| Adjunct Associate Professor, Institute of Biophotonics, and Institute of Biomedical | ||
| Engineering, National Yang-Ming University | ||
| Lab members | ||
Postdoctoral researchers: Tom Kwang-Chun Kuo, Yu-Peng Liu, Yi-Shiuan Liu Technician: Shu-Wen Kuo Administration assistant: Man-Chun Chuang, Han-Ying Chuang, Pei-Tsen Shih Research assistants: Hao-Hsiang Wu, Yun-Min Sung, Yu-Fan Chen, Tzu-Ching Tseng, Wei-Hsien Ma, Ming-Hsiang Chen, Chien-Chih Ke, Yang-Hsin Yu, Ya-Hui Hsu Graduate students: Hsin-Lin Tsai, Jei-Wen Chang, Ting Tina Lo, Hsiu-Yu
Lai, Shun-Pei Hung, Yu-Ru Vernon Shih, Yi-Chung Kuo, Wei-Cheng Jiang,
Chia-Yu Hou, Chien-Ting Tina Cheng, Pei-Ju Liu, Po-Hsin Chou, Yu-Tzu
Tsao, Chih-Yu Yang, Yu-Ping Su, You-Kang Chang (Co-supervising) |
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| Research Interests | ||
| Stem cell biology,Musculoskeletal research,Tissue engineering | ||
Recent Publications |
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Best
Research Award, Great
Academic Achievement Award at the 50th Anniversary of Academia
Sinica Research Award for Junior Research Investigators, Life Science
Award, 2009 Outstanding
Research Award, National Science The
Outstanding Young Persons of Taiwan
Who’s who in 2008 International
Who’s Who 2006-2007 Wu
Ta-Yu Memorial Award, National Science Best
Research Award, New
Investigator Recognition Award, 50th Annual Meeting of
Orthopedic Research Society, March 4-7, 2004, Best
Paper Award, Annual Meeting of Best
Paper Award, Annual Meeting of II.
Publications (selected from 2004) 1.
Ho
JH, Su Y, Chen KH, Lee OK*.
2010 Jun. [in press] Protection of thymosin beta-4 on corneal endothelial
cells from UVB-induced apoptosis. Chinese
J Physiol 53(3) (IF=0.655;
PHYSIOLOGY: 68/74) 2.
Ho JH, Ma WH, Su Y, Tseng KC,
Kuo TK, Lee OK*. 2010 Jan.
Thymosin beta-4 directs cell fate determination of human mesenchymal
stem cells through biophysical effects. J Orthop
Res 28(1): 131-138 (IF=2.963;
ORTHOPEDICS: 4/49) 3.
Kuo TK, Ho JH*, Lee OK*. 2009. Mesenchymal stem cell
therapy for non-musculoskeletal diseases: emerging applications. Cell
Transplantation 18(9): 1013-1028 (review) (IF=5.251; TRANSPLANTATION: 2/21) 4.
5.
Yang YC, Wang SW, Wu IC, Chang
CC, Huang YL, Lee OK, Chang
JG, Chen A, Kuo FC, Wang WM, Wu DC. 2009 Sep. A tumorigenic homeobox
(HOX) gene expressing human gastric cell line derived from putative
gastric stem cell. European Journal of Gastroenterology & Hepatology
21(9): 1016-1023 (IF=2.080; GASTROENTEROLOGY & HEPATOLOGY: 33/55) 6.
7.
Shih YR, Kuo TK, Yang AH, Lee OK*, Lee CH*. 2009 Aug. Isolation and characterization
of stem cells from the human parathyroid gland. Cell Proliferation
42(4): 461-470 (IF=2.423;
CELL BIOLOGY: 92/157) 8.
9.
Lien CY, Ho KC, Lee OK, Blunn GW, Su Y. 2009 May. Restoration
of bone mass and strength in glucocorticoid-treated mice by systemic
transplantation of CXCR4 and Cbfa-1 co-expressing mesenchymal stem
cells. J Bone Miner Res 24(5): 837-848 (IF=6.443; ENDOCRINOLOGY & METABOLISM: 9/93) 10. Sun LY, Hsieh DK, Yu TC, Chiu
HT, Lu SF, Luo GH, Kuo TK, Lee
OK*, Chiou TW*. 2009 May. Effect
of pulsed electromagnetic field on the proliferation and differentiation
potential of human bone marrow mesenchymal stem cells. Bioelectromagnetics
30(4): 251-260 (IF=2.062;
BIOLOGY: 22/71) 11. Su YP, Lee OK, Chen WM, Chen TH. 2009 Mar. A facile technique to make articulating
spacers for infected total knee arthroplasty. J Chin Med Assoc 72(3):
138-145 12. Chen YT, Chen WM, Chen CF, Lee OK, Chiang CC, Huang CK, Chen TH.
2008 Sep. Treatment of early osteonecrosis of the femoral head by
core decompression with trochanteric bone-grafting. J Orthop Surg
13. Hu MH, Chen WM, Chen CF, Lee OK, Chiang CC, Huang CK, Chen TH.
2008 Sep. Two-stage treatment of late chronic infected total knee
arthroplasty using an antibiotic-impregnated cement spacer. J Orthop
Surg 14. Guo HW, Chen CT, Wei YH, Lee OK, Gukassyan V, Kao FJ, Wang HW.
2008 Sep-Oct. Reduced nicotinamide adenine dinucleotide fluorescence
lifetime separates human mesenchymal stem cells from differentiated
progenies. J Biomed Opt 13(5): 050505 (IF=2.970;
OPTICS: 5/64) 15. Lin TC, Lee OK*. 2008 Aug. Stem cells: a primer. Chinese J Physiol 51(4):
197-207 (review) (IF=0.655;
PHYSIOLOGY: 68/74) 16. Fan CY, Chen WM, Lee OK, Huang CK, Chiang CC,
Chen TH. 2008
Aug. Acetabular revision arthroplasty using jumbo cups: an experience
in 17. Ho JH, Tseng KC, Ma WH, Chen
KH, Lee OK, Su Y. 2008 Jul.
Thymosin beta-4 upregulates anti-oxidative enzymes and protects human
cornea epithelial cells against oxidative damage. Brit J Ophthalmol
92(7): 992-997 (IF=2.859; OPHTHALMOLOGY: 10/48) 18.
Kuo TK, Hung SP, Chuang CH, Chen
CT, Shih YV, Fang SY, Yang VW, Lee
OK*. 2008 Jun. Stem cell therapy
for liver disease: Parameters governing the success of using bone
marrow mesenchymal stem cells. Gastroenterology 134(7): 2111-2121
(editorial highlight) (IF=12.591;
GASTROENTEROLOGY & HEPATOLOGY: 1/55) 19.
20. Lee
OK*. 2008 Feb. Fibrin glue as a vehicle for mesenchymal
stem cell delivery in bone regeneration. J Chin Med Assoc 71(2): 59-61 21. Li CH, Chen TH, Su YP, Shao PC,
Lee KS, Chen WM. 2008 Feb.
Periprosthetic femoral supracondylar fracture after total knee arthroplasty
with navigation system. J Arthroplasty 23(2):304-307 (IF=1.556; ORTHOPEDICS: 23/49) 22.
23.
Lien CY, Lee OK*, Su Y*. 2007 Jun. Cbfb enhances the osteogenic
differentiation of both human and mouse mesenchymal stem cells induced
by Cbfa-1 via reducing its ubiquitination-mediated degradation. Stem
Cells 25(6): 1462-1468 (IF=7.741;
BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 4/144) 24.
Ho JH, Chuang CH, Ho CY, Shih
YV, Lee OK*, Su Y*. 2007 Jan. Internalization is essential for the anti-apoptotic
effects of exogenous thymosin beta-4 on human corneal epithelial cells.
Invest Ophth Vis Sci 48: 27-33 (IF=3.582; OPHTHALMOLOGY: 4/48) 25. Shih
YV, Chen CN, Tsai SW, Wang YJ, Lee
OK*.
2006 Nov. Growth of mesenchymal
stem cells on electrospun type I collagen nanofibers. Stem Cells 24(11):
2391-2397 (Cover Feature) (IF=7.741; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 4/144) 26. Chou
SH, Kuo TK, Liu M, Lee OK*.
2006 Jan. In utero transplantation
of human bone marrow-derived multipotent mesenchymal stem cells in
mice. J Orthop Res 24: 301-312 (IF=2.963;
ORTHOPEDICS: 4/49) 27. Lee OK, Coathup MJ,
Goodship AE, Blunn GW. 2005 Nov-Dec. Use of mesenchymal stem cells
to facilitate bone regeneration in normal and chemotherapy-treated
rats. Tissue Eng 11: 1727-1735 (IF=4.697;
BIOTECHNOLOGY & APPLIED MICROBIOLOGY:13/144) 28. Lee KD, Kuo TK, Chung YF, Lin
CT, Chen JR, Chen YP, Lee OK*. 2004 Dec. In vitro hepatic
differentiation of human mesenchymal stem cells. Hepatology 40: 1275-1284 (editorial highlight) (IF=11.355; GASTROENTEROLOGY & HEPATOLOGY: 2/55) 29. Lee OK, Ko YC, Kuo TK, Chou SH, Lee
HJ, Chen WM, Chen TH, Su Y. 2004 Nov. Fluvastatin and lovastatin but
not pravastatin induce neuroglial differentiation in human mesenchymal
stem cells. J Cell Biochem 93: 917-928 (IF=3.540;
BIOCHEMISTRY & MOLECULAR BIOLOGY: 91/276) 30.
Chen CF, Chen WM, Lee KS, Huang CK, Chen TH. 2004 Sep. Advanced
osteoarthritic knee with neglected patellar tendon rupture treated
with total patellectomy and total knee arthroplasty. J Arthroplasty
19(6): 793-796
(IF=1.556; ORTHOPEDICS: 23/49) 31.
Lee
OK*, Kuo TK, Chen WM, Lee KD, Hsieh
SL, Chen TH. 2004 Mar. Isolation of multipotent mesenchymal
stem cells from umbilical cord blood. Blood 103: 1669-1675 (Cover Feature) (IF=10.432; HEMATOLOGY: 2/62) |
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