Postdoctoral researchers: Tom Kwang-Chun Kuo, Yi-Shiuan Liu
Technician: Shu-Wen Kuo
Administration assistant: Ko-Chen Chen, Yu-Ting Lo, Chia Ching Lin

Research assistants: Hao-Hsiang Wu, Yu-Fan Chen, Tzu-Ching Tseng, Wei-Hsien Ma, Hsin-Yu Yang, Jian-Wei Li, Hui-Wen Yang, Wei-Qi Wang
Graduate students: Hsin-Lin Tsai, Jei-Wen Chang, Ting Tina Lo, Hsiu-Yu Lai, Shun-Pei Hung, Yu-Ru Vernon Shih, Yi-Chung Kuo, Wei-Cheng Jiang, Chia-Yu Hou, Chien-Ting Tina Cheng, Pei-Ju Liu, Po-Hsin Chou, Yu-Tzu Tsao, Chien-Chih Ke , Pei-Shan Hung, Nan-Yuan Teng, Wen-Ding Xie, Shu-Wei Huang, Chih-Yu Yang, Yu-Ping Su, Yi-Hung Chiang, You-Kang Chang (Co-supervising)

I. Selected Awards

Best Research Award, Taipei Veterans General Hospital, 2009

Great Academic Achievement Award at the 50th Anniversary of Taipei Veterans General Hospital, 2009

Academia Sinica Research Award for Junior Research Investigators, Life Science Award, 2009

Outstanding Research Award, National Science Council, Taiwan, 2008

The Outstanding Young Persons of Taiwan, Medical Research Award, 2008

Taipei Veterans General Hospital Citation Classic Award, 2008

Taiwan Who’s who in 2008

International Who’s Who 2006-2007

Wu Ta-Yu Memorial Award, National Science Council, Taiwan, 2006

Best Research Award, Taipei Veterans General Hospital, 2005

New Investigator Recognition Award, 50^th Annual Meeting of Orthopedic Research Society, March 4-7, 2004, San Francisco, CA, USA

Best Paper Award, Annual Meeting of Taiwan Orthopaedic Association, 2003

Best Paper Award, Annual Meeting of Taiwan Orthopaedic Association, 2002

II. Publications (selected from 2004)

1.      Ho JH, Ma WH, Tseng TC, Chen YF, Chen, MH, Lee OK*. 2010 Aug. [accepted] Isolation and Characterization of Multi-Potent Stem Cells from Human Orbital Fat Tissues. Tissue Eng Part A _{(IF=4.582; BIOTECHNOLOGY & APPLIED MICROBIOLOGY:13/144)}

2.      Cheng MT, Liu CL, Chen TH, Lee OK*. 2010 Jul. Comparison of potentials between stem cells isolated from human anterior cruciate ligament and bone marrow for ligament tissue engineering. Tissue Eng Part A 16(7): 2237-2253 _{(IF=4.582; BIOTECHNOLOGY & APPLIED MICROBIOLOGY:13/144)}

3.      Ho JH, Su Y, Chen KH, Lee OK*. 2010 Jun. Protection of thymosin beta-4 on corneal endothelial cells from UVB-induced apoptosis. Chinese J Physiol 53(3):190-195 _{(IF=0.655; PHYSIOLOGY: 68/74)}

4.      Chang JW, Hung SP, Wu HH, Wu WM, Yang AH, Tsai HL, Yang LY, Lee OK*. 2010 May. [accepted] Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplantation _{(IF=5.251; TRANSPLANTATION: 2/21)}

5.      Lai HY, Yang MJ, Wen KC, Chao KC, Shih CC, Lee OK*. 2010 Apr. [accepted] Mesenchymal stem cells negatively regulate dendritic lineage commitment of umbilical cord blood derived hematopoietic stem cells- an unappreciated mechanism as immuno-modulators. Tissue Eng Part A _{(IF=4.582; BIOTECHNOLOGY & APPLIED MICROBIOLOGY:13/144)}

6.      Ho JH, Ma WH, Su Y, Tseng KC, Kuo TK, Lee OK*. 2010 Jan. Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects. J Orthop Res 28(1): 131-138 _{(IF=2.963; ORTHOPEDICS: 4/49)}

7.      Kuo TK, Ho JH*, Lee OK*. 2009. Mesenchymal stem cell therapy for non-musculoskeletal diseases: emerging applications. Cell Transplantation 18(9): 1013-1028 (review) _{(IF=5.251; TRANSPLANTATION: 2/21)}

8.      Cheng MT, Yang HW, Chen TH, Lee OK*. 2009 Dec. Modulation of proliferation and differentiation of human anterior cruciate ligament derived stem cells by different growth factors. Tissue Eng Part A 15(12): 3979-3989 _{(IF=4.582; BIOTECHNOLOGY & APPLIED MICROBIOLOGY:13/144)}

9.      Yang YC, Wang SW, Wu IC, Chang CC, Huang YL, Lee OK, Chang JG, Chen A, Kuo FC, Wang WM, Wu DC. 2009 Sep. A tumorigenic homeobox (HOX) gene expressing human gastric cell line derived from putative gastric stem cell. European Journal of Gastroenterology & Hepatology 21(9): 1016-1023 _{(IF=2.080; GASTROENTEROLOGY & HEPATOLOGY: 33/55)}

10.  Wu PK, Chen WM, Chen CF, Lee OK, Haung CK, Chen TH. 2009 Aug. Primary osteogenic sarcoma with pulmonary metastasis: clinical results and prognostic factors in 91 patients. Jpn J Clin Oncol 39(8): 514-522 _{(IF=1.405; ONCOLOGY; 120/143)}

11.  Shih YR, Kuo TK, Yang AH, Lee OK*, Lee CH*. 2009 Aug. Isolation and characterization of stem cells from the human parathyroid gland. Cell Proliferation 42(4): 461-470 _{(IF=2.423; CELL BIOLOGY: 92/157)}

12.  Cheng MT, Yang HW, Chen TH, Lee OK*. 2009 Aug. Isolation and characterization of multi-potent stem cells from human cruciate ligaments. Cell Proliferation 42(4): 448-460 _{(IF=2.423; CELL BIOLOGY: 92/157)}

13.  Lien CY, Ho KC, Lee OK, Blunn GW, Su Y. 2009 May. Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and Cbfa-1 co-expressing mesenchymal stem cells. J Bone Miner Res 24(5): 837-848 _{(IF=6.443; ENDOCRINOLOGY & METABOLISM: 9/93)}

14.  Sun LY, Hsieh DK, Yu TC, Chiu HT, Lu SF, Luo GH, Kuo TK, Lee OK*, Chiou TW*. 2009 May. Effect of pulsed electromagnetic field on the proliferation and differentiation potential of human bone marrow mesenchymal stem cells. Bioelectromagnetics 30(4): 251-260 _{(IF=2.062; BIOLOGY: 22/71)}

15.  Su YP, Lee OK, Chen WM, Chen TH. 2009 Mar. A facile technique to make articulating spacers for infected total knee arthroplasty. J Chin Med Assoc 72(3): 138-145

16.  Chen YT, Chen WM, Chen CF, Lee OK, Chiang CC, Huang CK, Chen TH. 2008 Sep. Treatment of early osteonecrosis of the femoral head by core decompression with trochanteric bone-grafting. J Orthop Surg Taiwan 25(3): 134-140

17.  Hu MH, Chen WM, Chen CF, Lee OK, Chiang CC, Huang CK, Chen TH. 2008 Sep. Two-stage treatment of late chronic infected total knee arthroplasty using an antibiotic-impregnated cement spacer. J Orthop Surg Taiwan 25(3): 113-120

18.  Guo HW, Chen CT, Wei YH, Lee OK, Gukassyan V, Kao FJ, Wang HW. 2008 Sep-Oct. Reduced nicotinamide adenine dinucleotide fluorescence lifetime separates human mesenchymal stem cells from differentiated progenies. J Biomed Opt 13(5): 050505 _{(IF=2.970; OPTICS: 5/64)}

19.  Lin TC, Lee OK*. 2008 Aug. Stem cells: a primer. Chinese J Physiol 51(4): 197-207 (review) _{(IF=0.655; PHYSIOLOGY: 68/74)}

20.  Fan CY, Chen WM, Lee OK, Huang CK, Chiang CC, Chen TH. 2008 Aug. Acetabular revision arthroplasty using jumbo cups: an experience in Asia. Arch Orthop Trauma Surg 128(8): 809-813 _{(IF= 0.965; ORTHOPEDICS: 31/49)}

21.  Ho JH, Tseng KC, Ma WH, Chen KH, Lee OK, Su Y. 2008 Jul. Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage. Brit J Ophthalmol 92(7): 992-997 _{(IF=2.859; OPHTHALMOLOGY: 10/48)}

22.  Kuo TK, Hung SP, Chuang CH, Chen CT, Shih YV, Fang SY, Yang VW, Lee OK*. 2008 Jun. Stem cell therapy for liver disease: Parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 134(7): 2111-2121 (editorial highlight) _{(IF=12.591; GASTROENTEROLOGY & HEPATOLOGY: 1/55)}

23.  Chen CT, Shih YV, Kuo TK, Lee OK*, Wei YH*. 2008 Apr. Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 26(4): 960-968  _{(IF=7.741; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 4/144)}

24.  Lee OK*. 2008 Feb. Fibrin glue as a vehicle for mesenchymal stem cell delivery in bone regeneration. J Chin Med Assoc 71(2): 59-61

25.  Li CH, Chen TH, Su YP, Shao PC, Lee KS, Chen WM. 2008 Feb. Periprosthetic femoral supracondylar fracture after total knee arthroplasty with navigation system. J Arthroplasty 23(2):304-307 _{(IF=1.556; ORTHOPEDICS: 23/49)}

26.  Chen YT, Chen WM, Lee KS, Hunag CK, Chiang CC, Chen TH. 2008 Feb. Diaphyseal locking hip arthroplasty for treatment of failed fixation of intertrochanteric hip fractures. J Arthroplasty 23(2):241-246 _{(IF=1.556; ORTHOPEDICS: 23/49)}

27.  Lien CY, Lee OK*, Su Y*. 2007 Jun. Cbfb enhances the osteogenic differentiation of both human and mouse mesenchymal stem cells induced by Cbfa-1 via reducing its ubiquitination-mediated degradation. Stem Cells 25(6): 1462-1468 _{(IF=7.741; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 4/144)}

28.  Ho JH, Chuang CH, Ho CY, Shih YV, Lee OK*, Su Y*. 2007 Jan. Internalization is essential for the anti-apoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells. Invest Ophth Vis Sci 48: 27-33 _{(IF=3.582; OPHTHALMOLOGY: 4/48)}

29.  Shih YV, Chen CN, Tsai SW, Wang YJ, Lee OK*. 2006 Nov. Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. Stem Cells 24(11): 2391-2397 (Cover Feature) _{(IF=7.741; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 4/144)}

30.  Chou SH, Kuo TK, Liu M, Lee OK*. 2006 Jan. In utero transplantation of human bone marrow-derived multipotent mesenchymal stem cells in mice. J Orthop Res 24: 301-312 _{(IF=2.963; ORTHOPEDICS: 4/49)}

31.  Lee OK, Coathup MJ, Goodship AE, Blunn GW. 2005 Nov-Dec. Use of mesenchymal stem cells to facilitate bone regeneration in normal and chemotherapy-treated rats. Tissue Eng 11: 1727-1735 _{(IF=4.697; BIOTECHNOLOGY & APPLIED MICROBIOLOGY:13/144)}

32.  Lee KD, Kuo TK, Chung YF, Lin CT, Chen JR, Chen YP, Lee OK*. 2004 Dec. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40: 1275-1284 (editorial highlight) _{(IF=11.355; GASTROENTEROLOGY & HEPATOLOGY: 2/55)}

33.  Lee OK, Ko YC, Kuo TK, Chou SH, Lee HJ, Chen WM, Chen TH, Su Y. 2004 Nov. Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells. J Cell Biochem 93: 917-928 _{(IF=3.540; BIOCHEMISTRY & MOLECULAR BIOLOGY: 91/276)}

34.  Chen CF, Chen WM, Lee KS, Huang CK, Chen TH. 2004 Sep. Advanced osteoarthritic knee with neglected patellar tendon rupture treated with total patellectomy and total knee arthroplasty. J Arthroplasty 19(6): 793-796 _{(IF=1.556; ORTHOPEDICS: 23/49)}

35.  Lee OK*, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH. 2004 Mar. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103: 1669-1675 (Cover Feature) _{(IF=10.432; HEMATOLOGY: 2/62)}